Molecular-modelling and biophysical studies on modified and unmodified oligonucleotides
نویسندگان
چکیده
منابع مشابه
Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides.
We report the synthesis of a 5-formyl-2'-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.
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چکیده ندارد.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1984
ISSN: 0108-7673
DOI: 10.1107/s010876738409838x